Yttrium-Catalyzed ortho-Selective C H Borylation of Pyridines with Pinacolborane

Yuncong Luo, Shengjie Jiang, and Xin Xu^*（徐信）

Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science，Soochow University，Suzhou 215123 (P. R. China)

Angew. Chem. Int. Ed. 2022, 61, e202117750

The ortho-selective C−H borylation of a wide range of pyridines using pinacolborane was achieved through yttrium catalysis. Notably, the possible hydroboration side reaction was effectively suppressed by using the proper ligand/metal combination. The resultant 2-pyridyl boronates were subjected to further transformations such as a Suzuki–Miyaura coupling or the Chan–Lam amination.

链接：https://onlinelibrary.wiley.com/doi/full/10.1002/anie.202117750