Yttrium-Catalyzed ortho-Selective C H Borylation of Pyridines with Pinacolborane
Yuncong Luo, Shengjie Jiang, and Xin Xu*（徐信）
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science，Soochow University，Suzhou 215123 (P. R. China)
Angew. Chem. Int. Ed. 2022, 61, e202117750
The ortho-selective C−H borylation of a wide range of pyridines using pinacolborane was achieved through yttrium catalysis. Notably, the possible hydroboration side reaction was effectively suppressed by using the proper ligand/metal combination. The resultant 2-pyridyl boronates were subjected to further transformations such as a Suzuki–Miyaura coupling or the Chan–Lam amination.