Palladium-Catalyzed Isoquinoline Synthesis by Tandem C−H Allylation and Oxidative Cyclization of Benzylamines with Allyl Acetate
Yujie Chen1, Zhibin Huang1,*（黄志斌）, Chenyang Dai1, Shan Yang1, Da-Qing Shi1,*（史达清）, and Yingsheng Zhao1,2,*（赵应声）
1Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P. R. China
2School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453000, P.R.China
Org. Lett. 2021, 23(11) , 4209--4213
A novel approach to synthesize 3-methylisoquinolines via a one-pot, two-step, palladium(II)-catalyzed tandem C–H allylation/intermolecular amination and aromatization is reported. A wide series of 3-methylisoquinoline derivatives were obtained directly using this method in moderate to good yields, and we highlight the synthetic importance of this new transformation.
链接：https://pubs.acs.org/doi/abs/10.1021/acs.orglett.1c01153