[3 + 2] Cycloaddition of Nitrile Ylides with Diazonium Salts: Copper-Catalyzed One-Pot Synthesis of Fully Substituted 1,2,4-Triazoles

Huihuang Li, Xueli Wu, Weiwei Hao, Haiyan Li, Yanwei Zhao, Yaxiong Wang, Pengcheng Lian, Yonggao Zheng, Xiaoguang Bao^*（鲍晓光）, and Xiaobing Wan^*（万小兵）

Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, People’s Republic of China

Org. Lett., 2018, 20 (17), 5224--5227

A novel [3 + 2] cycloaddition between nitrile ylides and diazonium salts was well-established. This copper-catalyzed three-component reaction was distinguished by mild conditions, ready availability, and operational simplicity, thus opening access to 1,2,4-triazoles with a diverse set of substitution patterns.

链接：https://pubs.acs.org/doi/10.1021/acs.orglett.8b02172