Palladium-Catalyzed Incorporation of Two C1 Building Blocks: The Reaction of Atmospheric CO₂ and Isocyanides with 2-Iodoanilines Leading to the Synthesis of Quinazoline-2,4(1H,3H)-diones

Pei Xu, Fei Wang, Tian-Qi Wei, Ling Yin, Shun-Yi Wang^*（汪顺义）, and Shun-Jun Ji^*（纪顺俊）

Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, China

Org. Lett., 2017, 19 (17), 4484--4487

A Pd-catalyzed insertion and cycloaddition of CO₂ and isocyanide into 2-iodoanilines under atmospheric pressure has been developed and affords quinazoline-2,4(1H,3H)-diones through the formation of new C–C, C–O, and C–N bonds under mild conditions. This reaction provides a new and practical method not only for the construction of quinazoline-2,4(1H,3H)-diones but also for the efficient utilization of carbon dioxide.

链接：http://pubs.acs.org/doi/abs/10.1021/acs.orglett.7b01877