Synergistic Strategies of Cyano Migration and Photocatalysis for Difunctionalization of Unactivated Alkenes: Synthesis of Di- and Mono-Fluorinated Alkyl Nitriles

Rongguo Ren, Zhen Wu, Leitao Huan, Chen Zhu*（朱晨）

Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science Soochow University, Suzhou, Jiangsu, People's Republic of China

ADVANCED SYNTHESIS & CATALYSIS，2017， 359（17），3052--3056

A general protocol for the challenging cyanofluoroalkylation of unactivated alkenes is disclosed. A broad range of synthetically useful di- and mono-fluorinated alkyl nitriles are readily obtained in good yields under mild reaction conditions. The efficient combination of intramolecular cyano migration and photoredox catalysis significantly expands the field of difunctionalization of olefins.

链接：http://onlinelibrary.wiley.com/doi/10.1002/adsc.201700591/full