Merging Distal Alkynyl Migrationand PhotoredoxCatalysis for Radical TrifluoromethylativeAlkynylation of Unactivated Olefins
Yan Xu1, Zhen Wu1, Jingxing Jiang2, Zhuofeng Ke2, Chen Zhu*，1（朱晨）
1Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Jiangsu, China
2School of Materials Science and Engineering, Sun Yat-sen University, Guangdong, China
Angew.Chem.Int.Ed.2017,56,4545–4548
Disclosed herein is a novel, redox-neutral protocol for the visible-light-induced radical alkynylation of unactivated olefins. The intramolecular migration of an alkynyl group, by cleaving an inert C−C σ bond, is realized for the first time. A wide range of synthetically useful trifluoroethylated linear alkynes are readily obtained under mild reaction conditions.
链接：http://onlinelibrary.wiley.com/doi/10.1002/anie.201700413/abstract