Heterocyclization Reagents for Rapid Assembly of N-Fused Heteroarenes from Alkenes

Huihui Zhang¹, Min Wang¹, Xinxin Wu¹, and Chen Zhu^1,2,*（朱晨）

¹Key Laboratory of Organic Synthesis of Jiangsu Province，College of Chemistry, Chemical Engineering and Materials Science，Soochow University，199 Ren-Ai Road, Suzhou, Jiangsu 215123 (China)

¹Key Laboratory of Synthetic Chemistry of Natural Substances，Shanghai Institute of Organic Chemistry，Chinese Academy of Sciences，345 Lingling Road, Shanghai 200032 (China)

Angew. Chem. Int. Ed. 2021, 60, 3714--3719

N‐Fused heterocycles are of particular use and upmost importance in multiple fields. Herein, we disclose a conceptually new approach for the rapid assembly of N‐fused heteroarenes from alkenes. A portfolio of strategically designed heterocyclization reagents are readily prepared for the cascade reaction. A plethora of N‐fused heteroarenes including seven types of heterocyclic core are furnished. The protocol features a broad functional‐group compatibility and high product diversity, and provides a practical tool for late‐stage heteroarene elaboration.

链接：https://onlinelibrary.wiley.com/doi/epdf/10.1002/anie.202013089