PEGylated Au@Pt Nanodendrites as Novel Theranostic Agents for Computed Tomography Imaging and Photothermal/Radiation Synergistic Therapy

Xu Liu^†, Xing Zhang^§, Mo Zhu^‡, Guanghui Lin^∥, Jian Liu^⊥, Zhufa Zhou^†, Xin Tian^*@（田欣）, and Yue Pan^*†（潘越）

^† State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China

^‡ Department of Radiology, The First Affiliated Hospital of Soochow University, 188, Shi Zi Road, Suzhou 215006, China

^§ Shenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China

^∥ Printable Electronics Research Centre, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, China

^⊥ Institute of Functional Nano and Soft Materials (FUNSOM), Soochow University, Suzhou 215123, China

^@ School of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X) & Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, China

ACS Appl. Mater. Interfaces, 2017, 9 (1), pp 279–285

The integration of photothermal therapy (PTT) with radiation therapy (RT) in a single nanoscale platform is believed to have considerable potential for cancer therapy. In this work, the rationally designed PEGylated Au@Pt nanodendrites (NDs) have been developed as a novel X-ray computed tomography (CT) and PTT/RT enhanced theranostic agent for cancer therapy. The absorption of Au@Pt NDs was turned to the near-infrared region with the growth of Pt nanobranches and thus enhances the efficacy of PTT. Furthermore, because of the high atomic number (high Z) of Au as well as Pt, Au@Pt NDs significantly enhanced lethal effects of RT by inducing a highly localized radiation dose within cancer cells. More importantly, the combination of Au@Pt ND-enhanced RT with PTT suppressed cancer cell growth more efficiently than that RT or PTT alone did, indicating a synergistic effect. Meanwhile, the Au@Pt NDs also possess significant CT imaging signal enhancement that has the potential to guide PTT/RT for cancers. The integrated strategy significantly improved CT and PTT/RT of cancer cells with mild laser and radiation. Because of these advantages, Au@Pt NDs have become appealing and effective agents for cancer theranostic.

链接：http://pubs.acs.org/doi/abs/10.1021/acsami.6b15183