Rhodium(III)-Catalyzed Selective Monoarylation of β or γ C(sp³)–H Bonds Assisted by a Trimethylpyrazole Group

Chunchen Yuan, Guangliang Tu, and Yingsheng Zhao^*（赵应声）

Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China

Org. Lett., 2017, 19 (2), pp 356–359

The selective arylation of unactivated β or challenging γ primary and secondary β-C(sp³)–H bonds has been developed with a Cp*Rh(III) catalyst assisted by a trimethylpyrazole group. A rarely reported six-membered rhodacycle has been identified in rhodium-catalyzed C(sp³)–H activation reactions. Preliminary mechanistic studies have revealed that a concerted metalation–deprotonation pathway might be involved in the C–H activation step.

链接：http://pubs.acs.org/doi/abs/10.1021/acs.orglett.6b03522