万小兵教授在Org. Biomol. Chem. 上发表研究论文

In situ generation of nitrilium from nitrile ylide and the subsequent Mumm rearrangement: copper-catalyzed synthesis of unsymmetrical diacylglycine esters

Jijun Chen,^aYing Shao,^abLiang Ma,^aMeihua Ma^a and   Xiaobing Wan*^a（万小兵）

^a Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China

^bJiangsu Key Laboratory of Advanced Catalytic Materials and Technology, Advanced Catalysis and Green Manufacturing Collaborative Innovation Center, Changzhou University, Changzhou, China

Org. Biomol. Chem., 2016,14, 10723-10732

A novel in situ generation of nitrilium from a nitrile ylide and the subsequent Mumm rearrangement of carboxylic acid, nitrile, and diazo compounds gave various unsymmetrical diacylglycine esters in moderate to high yields. This copper-catalyzed cascade reaction enables one-pot generation of two C–N bonds, one CO bond, and one C–H bond, with nitrogen as the only byproduct. The reaction has a broad functional-group tolerance, is rapid, easily scales up to the 100 mmol scale, and is insensitive to air and moisture.

链接：http://pubs.rsc.org/en/Content/ArticleLanding/2016/OB/C6OB02037B#!divAbstract