a Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, 199 Ren-Ai Road, Suzhou, China
b Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China
Org. Chem. Front., 2016,3, 1467-1471
We disclose an efficient manganese-catalyzed ring-opening chlorination of cyclobutanols. This reaction has a broad substrate scope, affording a variety of γ-chloro alkyl ketones and medium-sized benzocyclic chlorides in synthetically useful yields and unique regioselectivities. The merits including mild reaction conditions and employment of inexpensive catalysts and reagents make it a practical approach for the production of γ-chlorinated ketones.
链接：http://pubs.rsc.org/en/Content/ArticleLanding/2016/QO/C6QO00443A#!divAbstract