Chemodivergent synthesis of multi-substituted/fused pyrroles via copper-catalyzed carbene cascade reaction of propargyl α-iminodiazoacetates
a Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P. R. China
Chem. Commun., 2016,52, 12470-12473
A novel cascade reaction of alkynyl-tethered α-iminodiazoacetates has been developed, which provides a general access to both multi-substituted and fused pyrroles in high yields with a broad substrate scope. The γ-imino carbene is proposed as the key intermediate in this divergent reaction and followed by unpresented transformations.
链接：http://pubs.rsc.org/en/Content/ArticleLanding/2016/CC/C6CC06864B#!divAbstract