Weijing Yang , Yan Zou , Fenghua Meng*（孟凤华） , Jian Zhang , Ru Cheng , Chao Deng and Zhiyuan Zhong *（钟志远）
Biomedical Polymers Laboratory and Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application College of Chemistry Chemical Engineering and Materials Science Soochow University Suzhou 215123 , P. R. China
Adv. Mater. 2016, 28, 8234–8239
Anisamide-functionalized reversibly crosslinked chimeric polymersomes emerge as an “all-function-in-one” nanoplatform for efficient loading and targeted delivery of methotrexate disodium, a potent water-soluble anticancer drug, to sigma receptor overexpressing H460 nonsmall lung cancer xenografts in vivo, leading to markedly improved tumor-growth inhibition and survival rate and depleted adverse effects as compared to the clinically used formulation (Trexall).
链接：http://onlinelibrary.wiley.com/doi/10.1002/adma.201600065/abstract;jsessionid=778E3C6B20634BD7D8ABB99C992E3ADB.f03t04