Co(acac)2/O2-catalyzed oxidative isocyanide insertion with 2-vinylanilines: efficient synthesis of 2-aminoquinolines
aKey Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, P. R. China
RSC Adv., 2016,6, 32467-32470
A series of 2-aminoquinolines were afforded by Co(acac)2 catalyzed isocyanide insertion with 2-vinylanilines under an O2 atmosphere. This reaction not only uses low toxicity Co(acac)2 as the catalyst and oxygen as the oxidant, but also allows the construction of new C(sp2)–C(sp2) and C(sp2)–N bonds in a single-step.
链接：http://pubs.rsc.org/en/content/articlelanding/2016/ra/c6ra03216h#!divAbstract