于谦副教授与李丹副教授合作在Mater. Horiz. 上发表研究论文

Hui Du ^a,   Cong Li ^a ,  Yafei Luan ^a,   Qi Liu ^a,   Weikang Yang ^a,   Qian Yu*^a  （于谦）, Dan Li*^a（李丹） ,  John L. Brash^ab and   Hong Chen^a 

^a State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, P. R. China

^b School of Biomedical Engineering and Department of Chemical Engineering, McMaster University, Hamilton, Canada

Mater. Horiz., 2016,3, 556-562

A novel concept of a thrombolytic material whose activity is triggered by the generation of a clot/thrombus is developed. The concept is realized using a tissue plasminogen activator (t-PA)-loaded hydrogel crosslinked by a thrombin-cleavable peptide. The hydrogel is shown to release t-PA in serum and dissolve fibrin clots only when thrombin (generated during clot formation) is present.

链接：http://pubs.rsc.org/en/content/articlelanding/2016/mh/c6mh00307a#!divAbstract