Decarboxylative and Deoxygenative/ Decarbonylative Alkylation of Heterocycles with α-Keto Acids
Zelin Zhao1, Qian Jing1, Haiqin Liu1, Nan Liu1, David James Young2, Zhi-Gang Ren1, Hong-Xi Li(李红喜)1*
1College of Chemistry, Chemical Engineering and Materials Science,Soochow University, Suzhou215123, China
2James Watt School of Engineering, University of Glasgow, Glasgow G128QQ, U.K
Org. Lett.2026, 28, 8, 2801–2806
Abstract: The visible-light-assisted, self-promoted decarboxylative and deoxygenative alkylation of heterocycles from aromatic α-keto acids has been achieved without an added transition-metal catalyst, photocatalyst, or reductant under 400 nm LED irradiation at room temperature. This methodology is mild, straightforward, and suitable for a wide range of substrates. The α-oxycarboxylic acids act as the reagent, photosensitizer, and reductant. Additionally, reaction of a heterocycle with secondary or tertiary alkyl keto acids gives decarboxylative and decarbonylative alkylated products.
Article information: https://doi.org/10.1021/acs.orglett.6c00440