张丽芬教授、程振平教授与放射医学与防护学院何伟伟副教授、功能纳米与软物质研究院程亮教授合作在Adv. Funct. Mater.上发表研究论文
Detachable Fluorinated Phthalocyanine Aggregates for Carrier-Free PDT: Effect of Axial Symmetry on Dynamic Morphological Adjustment and Photodynamic Efficiency
Shunhu Zhang1, Nailin Yang2, Haitao Zhao1, Shumin Sun2, Peidong Chen1, Chaowei Cheng1, Chunjie Wang2, Weiwei He3（何伟伟）*, Lifen Zhang1（张丽芬）*, Liang Cheng2（程亮）*, Zhenping Cheng1（程振平）*
1State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application Suzhou key Laboratory of Macromolecular Design and Precision Synthesis College of Chemistry Chemical Engineering and Materials Science Soochow University Suzhou 215123, China
2Institute of Functional Nano & Soft Materials (FUNSOM)Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices Soochow University Suzhou 215123, China
3State Key Laboratory of Radiation Medicine and Protection School of Radiological and Interdisciplinary Sciences (RADX) Soochow University Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions Suzhou 215123, China
Adv. Funct. Mater. 2026, 36, e13920
Abstract: Chemical structure plays a critical role in determining the properties and aggregation behavior of materials. In this study, controlled axial modification of one or two PEG5000 molecules is performed on the central metal (Sn) of the fluorinated phthalocyanine to obtain asymmetric and symmetric amphiphilic polymers, denoted as SnPcP and SnPc2P, respectively. The anisotropic aggregation of fluorinated phthalocyanine guides the construction of dynamic aggregates with diverse architectures. Dynamic aggregates can be formed by seed-growth at high concentrations in selective solvents, detaching into pseudo-axisymmetric J-aggregated oligomers (seeds, <20 nm) at low concentrations for the asymmetric SnPcP. For SnPc2P, the symmetrically entangled PEG prevents the orderly arrangement of fluorinated phthalocyanine and forms seeds independently; aggregates are preferred at high concentrations, and unimers (seeds, ca. 10 nm) can be obtained when diluted. Both photosensitizers (PSs) exhibit outstanding photostability and oxygen-carrying capacity, and additionally, SnPcP displays higher photodynamic efficiency at low concentrations, probably due to that J-aggregation elevates the intersystem crossing efficiency. In vitro and in vivo experiments demonstrate the extraordinary photodynamic therapy capacity of SnPcP. This study provides a universal strategy for the modular design of dynamic aggregates by constructing detachable PS primitives with pseudo/axisymmetric structures.
Article information: https://doi.org/10.1002/adfm.202513920