Dual-state emission probes with a decahydroquinoline-naphthalimide skeleton for cells and tissue imaging at low concentration
Qi Lin1, Wen-Pei Ni1, Wen-Juan Gan2, Xu Xu2, Ru Sun1*, Jian-Feng Ge1,3*
1College of Chemistry, Chemical Engineering and Material Science, Soochow University, No. 199 Ren Ai Road, Suzhou 215123, China
2Fourth Affiliated Hospital of Soochow University, No. 9 Chong’Wen Road, Suzhou 215123, China
3Jiangsu Key Laboratory of Medical Optics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Science, Suzhou 215163, China
Chem. Commun.,2025,61, 19501-19504
Abstract: Polarity-sensitive probes1a–1c exhibit dual-state emission (DSE) by increasing the twist angle between auxochrome and fluorogen. They can target specific organelles at 200 nM and distinguish cancer cells from normal cells. More importantly, the probes have the ability to differentiate the liver cancer tissue at different stages of differentiation.
Article information: https://doi.org/10.1039/D5CC05385D