Palladium-Catalyzed Direct C−H Arylation of 3‑Butenoic Acid Derivatives
Shan Yang1,§, Lingling Liu1,§, Zheng Zhou1,, Zhibin Huang1,*（黄志斌）, and Yingsheng Zhao1, 2,*（赵应声）
1 Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P. R. China
2 School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453000, P. R. China;
§S.Y. and L.L. contributed equally
Org. Lett. 2021, 23, 296--299
We report herein a direct method to synthesize 4-aryl-3-butenoic acid through a carboxylic-acid-directed oxidative Heck reaction. The various 4-aryl-3-butenoic acids are easily prepared in moderate to good yields. In view of the promising bioactivity of 4-phenyl-3-butenoic acid previously reported, its derivatives reported here may be bioactive.
链接：https://pubs.acs.org/doi/10.1021/acs.orglett.0c03773