Palladium-Catalyzed Carboxylate-Assisted Ethoxycarboxylation of Aromatic Acids To Synthesize Monoethyl Phthalate Derivatives with Ethyl Bromodifluoroacetate
Na Tao, Jie Wang, Chunchen Yuan, Runsheng Zeng*（曾润生）, and Ying-Sheng Zhao* （赵应声）
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China
Org. Lett.2019, 21, 8607--8610
A novel and efficient approach for direct carbonation of aromatic acids with ethyl bromodifluoroacetate as the carbonyl source is reported. A broad range of substrates bearing various functional groups were tolerated, leading to monoalkyl phthalate derivatives in moderate to good yields.
链接：https://pubs.acs.org/doi/10.1021/acs.orglett.9b03196