赵应声副教授与重庆大学蓝宇教授合作在 Angew. Chem. Int. Ed. 上发表研究论文

Ruthenium(II)-Catalyzed C@H Difluoromethylation of Ketoximes: Tuning the Regioselectivity from the meta to the para Position

Chunchen Yuan^1,+, Lei Zhu^2,+, Runsheng Zeng¹, Yu Lan^2,*（蓝宇）, and Yingsheng Zhao^1,*（赵应声）

¹ Key Laboratory of Organic Synthesis of Jiangsu Province

College of Chemistry, Chemical Engineering, and Materials Science

Soochow University,Suzhou 215123 (P.R. China)

² School of Chemistry and Chemical Engineering,Chongqing University,

Chongqing 40030 (P.R. China)

^[+] These authors contributed equally.

Angew. Chem. Int. Ed.2018, 57, 1277--1281

A highlypara‐selective C_Ar−H difluoromethylation of ketoxime ethers under ruthenium catalysis has been developed. A wide variety of ketoxime ethers are compatible with the reaction, which leads to the correspondingpara‐difluoromethylated products in moderate to good yield. A mechanistic study clearly showed that chelation‐assisted cycloruthenation is the key factor in theparaselectivity of the difluoromethylation of ketoxime ethers. Density functional theory was used to gain a theoretical understanding of theparaselectivity.

链接：https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201711221