Synthesis of One-Component Nanostructured Polyion Complexes via Polymerization-Induced Electrostatic Self-Assembly
Meng Cai†, Yi Ding†, Lei Wang, Leilei Huang, Xinhua Lu, and Yuanli Cai*（蔡远利）
College of Chemistry, Chemical Engineering and Materials Science, State-Local Joint Engineering Laboratory for Novel Functional
Polymer Materials, Soochow University, Suzhou 215123, China
†These authors contributed equally to this work.
ACS Macro Lett.2018, 7, 208--212
Nanostructured polyion complexes (PICs) are expected to serve as novel platforms to stabilize and deliver drugs, proteins, and nucleic acids. Yet, traditional self-assembly suffers from lack of scale-up and reproducibility. Particularly for one-component PICs, only spheres are available to date. Here, we report an efficient and scalable strategy to prepare one-component low-dimensional PICs. It involves visible-light-mediated RAFT iterative polymerization of opposite-charge monomers at 25% w/w solids in water at 25 °C. Sphere-film-vesicle transition and charge-/medium-tunable shape selectivity are reported. One-component PIC nanowire, ultrathin film, vesicle, tube, and surface-charged vesicle are easily prepared, and vesicle-polymerization is fulfilled, using this new strategy. This strategy provides a general platform to prepare one-component low-dimensional PICs with tailorable morphologies and high reproducibility on commercially viable scale under eco-friendly conditions.
链接：https://pubs.acs.org/doi/abs/10.1021/acsmacrolett.8b00005