Diastereodivergent synthesis of bispirooxindolesviaasymmetric Friedel–Crafts/aldol cascade reaction: co-catalyst effects on diastereoselective outcomes
Nai-Kai Li, Wei-Tai Fan, Jun-Qi Zhang, Bing-Bing Sun, Jun-Bo Chen and Xing-Wang Wang *（王兴旺）
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P. R. China.
Chem. Commun., 2018, 54, 2260--2263
A combination of metal- and organo-catalysts sequentially catalyzing the Friedel–Crafts/aldol tandem reaction between 3-pyrrolyl-oxindoles and isatin-derived β,γ-unsaturated α-ketoesters has been reported, which leads to two types of diastereomeric enantio-enriched bispirooxindoles with three quaternary stereocentres and synthetically valuable functional groups in high yields with excellent enantioselectivity and diastereoselectivity.
链接：http://pubs.rsc.org/en/Content/ArticleLanding/2018/CC/C7CC09489B#!divAbstract