曾润生副教授与赵应声副教授合作在JOURNAL OF ORGANIC CHEMISTRY 上发表研究论文

作者: 发布时间:2016-09-06 浏览次数:737

Pd-Catalyzed Coupling of gamma-C(sp(3))-H Bonds of Oxalyl Amide-Protected Amino Acids with Heteroaryl and Aryl Iodides

Han, J1 ; Zheng, YX 1; Wang, C1; Zhu, Y 1 ; Huang, ZB1; Shi, DQ1; Zeng, RS*1(曾润生); Zhao, YS*1(赵应声)

 

Soochow Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Organ Synth Jiangsu Prov, Suzhou 215123, Peoples R China.

 

JOURNAL OF ORGANIC CHEMISTRY ,2016, 81, 13, 5681-5689

 

Pd-catalyzed regioselective coupling of gamma-C-(sp(3))-H bonds of oxalyl amide-protected amino acids with heteroaryl and aryl iodides is reported. A wide variety of iodides are tolerated, giving the corresponding products in moderate to good yields. Various oxalyl amide-protected amino acids were compatible in this C-H transformation, thus representing a practical method for constructing non-natural amino acid derivatives.

 

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