Han, J1 ; Zheng, YX 1; Wang, C1; Zhu, Y 1 ; Huang, ZB1; Shi, DQ1; Zeng, RS1; Zhao, YS1
Soochow Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Organ Synth Jiangsu Prov, Suzhou 215123, Peoples R China.
JOURNAL OF ORGANIC CHEMISTRY ,2016, 81卷, 13期, 5681-5689
Pd-catalyzed regioselective coupling of gamma-C-(sp(3))-H bonds of oxalyl amide-protected amino acids with heteroaryl and aryl iodides is reported. A wide variety of iodides are tolerated, giving the corresponding products in moderate to good yields. Various oxalyl amide-protected amino acids were compatible in this C-H transformation, thus representing a practical method for constructing non-natural amino acid derivatives.
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