徐新芳教授与马里兰大学Michael P. Doyle教授合作在Chem. Sci.发表研究论文

Enantioselective cis-β-lactam synthesis by intramolecular C–H functionalization from enoldiazoacetamides and derivative donor–acceptor cyclopropenes

Xinfang Xu^*a(徐新芳),   Yongming Deng^b,   David N. Yim^b,   Peter Y. Zavalij^b  and   Michael P. Doyle^*b  

^a Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China

^b Department of Chemistry and Biochemistry, University of Maryland, College Park, USA

Chem. Sci. 2015, 6, 2196-2201

β-Lactam derivatives are produced through intermediate donor–acceptor cyclopropene intermediates in high yield, exclusive cis-diastereoselectivity, and high enantiocontrol in a chiral dirhodium carboxylate catalyzed intramolecular C–H functionalization reaction of enoldiazoacetamides.

链接：

http://pubs.rsc.org/en/Content/ArticleLanding/2015/SC/c4sc03991b#!divAbstract