黄志斌副教授与史达清教授合作在Green Chem.发表研究论文

GAP chemistry for pyrrolyl coumarin derivatives: a highly efficient one-pot synthesis under catalyst-free conditions

Huiyan Wang,^ab   Xuecheng Liu,^a   Xian Feng,^a   Zhibin Huang*^a （黄志斌）and   Daqing Shi*^a （史达清）

^a Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P.R. China

^b Department of Chemical Engineering, Huaihai Institute of Technology, Lianyungang 222005, P.R. China

Green Chem. 2013, 15, 3307-3311

A concise and efficient one-pot synthesis of pyrrolyl coumarin derivatives via a four-component reaction of 4-hydroxycoumarin, arylglyoxal monohydrate, dialkyl but-2-ynedioate and amines under catalyst-free conditions in an environmentally friendly medium (ethanol) is described. This synthesis was confirmed to follow the group-assisted-purification (GAP) chemistry process, which can avoid traditional chromatography and recrystallization purification methods.

链接：

http://pubs.rsc.org/en/content/articlelanding/2013/gc/c3gc41799a#!divAbstract