Highly efficient construction of pentacyclic benzo[b]indeno[1,2,3-de][1,8]- naphthyridine derivatives via four-component domino reaction
Cheng-Pao Cao(曹成跑), Wei Lin(林伟), Ming-Hua Hu(胡明华), Zhi-Bin Huang (黄志斌)*, Da-Qing Shi (史达清)*
Chem. Commun. 2013, 49, 6983-6985.
A series of new octahydrobenzo[b]indeno[1,2,3-de][1,8] naphthyridine and decahydropyrido[2,3,4-gh]phenanthridine derivatives were synthesized via a four-component domino reaction under microwave irradiation. This one-pot transformation, which involved multiple steps and did not require the use of a catalyst, constructed four new C–C bonds, two new C–N bonds, and three new rings, with efficient use of all reactants.
