题目：Unnatural Information-containing Macromolecules

报告人：Prof. Jean-FrançoisLutz

        Precision Macromolecular Chemistry,Institut Charles Sadron, 23 rue du Loess, 67034 Strasbourg, France

地点：907楼1445房间

时间：2015年10月24日(周六) 14:30-16:00

摘要：

Information-containingmacromolecules are polymers that contain a message encrypted in their comonomersequences. The archetypal example of such a polymer is DNA, which is used inbiology to store genetic information.[1] However, DNA is certainly not the onlypolymer that can contain molecular information.[2] In principle, a string ofinformation can be created in any copolymer using two comonomers definedintentionally as 0-bit and 1-bit. However, such polymers have to bemonodisperse and perfectly sequence-defined. In addition, the message encodedin their chains should be easily read.

Inthis lecture, I will present recent achievements obtained in my laboratory forthe synthesis of information-containing macromolecules. Recent progress in thefield of sequence-controlled polymers allows synthesis of unnaturalmacromolecules with precisely controlled primary and secondary structures.[3-6]For instance, monodisperse sequence-defined polymers were prepared usingchemoselective iterative strategies.[7] Furthermore, the readability of thesepolymers will be presented. For instance the sequencing of unnaturalsequence-defined copolymers by tandem mass spectrometry will be discussed.[7]

个人简介：

2009Habilitation - Universität Potsdam, Germany

2000Ph.D. (Diplôme de docteur) - Université Montpellier II, France

1996M.Sc. (Diplôme d’études approfondies, DEA) - Université Paris VI, France

1995B.Sc. (Maîtrise de Chimie) - Université Paris VI, France

SelectedPublications：

[1]Lutz, J.-F., Ouchi, M.; Liu, D. R.; Sawamoto, M. Science 2013, 341, 628.

[2]Colquhoun, H. M.; Lutz, J.-F. Nature Chem. 2014, 6, 455-456.

[3]Giuseppone, N.; Lutz, J.-F. Nature 2011, 473, 40-41.

[4]Lutz, J.-F. Nature Chem. 2010, 2, 84-85.

[5]Ouchi, M.; Badi, N.; Lutz, J.-F.; Sawamoto M. Nature Chem. 2011, 3, 917-924.

[6]Zamfir, M.; Lutz, J.-F. Nature Commun. 2012, 3, 1138.

[7]Roy, R. R.; Meszynska, A.; Laure, C.; Charles, L.; Lutz, J.-F. et al. NatureCommun. 2015, 6, 7237.

                                                                                             (报告联系人：张正彪老师）