Polarity-sensitive fluorescent probes based on imidazopyridazine derivatives for imaging lung cancer tissues
Huan Ma1, Hui Wang1, Xu Xu2, Ru Sun1, Yi Zhang2（张逸）*, Jian-Feng Ge1,3（葛健锋）*
1College of Chemistry, Chemical Engineering and Material Science, Soochow University, No. 199 Ren Ai Road, Suzhou 215123, China
2The Fourth Affiliated Hospital of Soochow University, Suzhou 215000, China
3Jiangsu Key Laboratory of Medical Optics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Science, Suzhou 215163, China
Chem. Commun.,2025,61, 11449-11452
Abstract:Two polarity-responsive probes,1a and1b, were prepared via Suzuki coupling. These probes targeted mitochondria and lipid droplets, respectively, enabling the monitoring of polarity changes. Probes1a and1b could indicate the difference between lung cancer tissues with different degrees of cellular differentiation, exhibiting fluorescence intensities that were 6.9–7.3-fold and 2.3–2.5-fold higher in poorly differentiated tissues than in highly and moderately differentiated tissues, respectively.
Article information: https://doi.org/10.1039/D5CC02637G
