学历及学术经历：苏州大学材料与化学化工学部副教授、硕士生导师。2010年毕业于兰州大学，获学士学位；2016年毕业于美国路易斯安那州立大学，获博士学位（导师：Donghui Zhang和Graca Vicente），之后前往美国劳伦斯伯克利国家实验室从事博士后研究（合作导师为：Ron Zuckermann）。2021年1月加入苏州大学材料与化学化工学部。迄今，在Angew. Chem., Int. Ed., J. Am. Chem. Soc., Proc. Natl. Acad. Sci., Macromolecules,ACS Macro. Lett., Biomacromolecules, ACS Appl. Mater. Interfaces, Sci. China Chem., Chem. Mater., Polym. Chem., J. Mater. Chem. B, Macromol. Rapid Commun., J. Org. Chem., J. Med. Chem.等国际著名期刊发表论文40余篇。主持国家自然科学青年基金、国家自然科学面上项目、江苏省自然科学青年基金、江苏省高等学校面上项目等多项。

研究领域：生物高分子材料的设计、合成、结构-性能关系研究及生物应用开发。自然界是分子材料设计的丰富灵感来源，我们致力于开发仿生（biomimetic）、生物启发（bioinspired）和生物源（bioderived）的结构明确的聚合物。研究方向主要包括：1）高效合成方法的开发；2）抗冻聚合物的设计与合成；3）抗菌聚合物的设计与合成；（4）药物（基因）递送载体的设计与合成。参与研究的学生不仅能学习聚合物合成关键技术和多种高分子表征分析方法，而且能熟悉与生物应用相关的知识和技术（如细胞培养、冷冻保存等）。热烈欢迎具有化学、材料背景的同学加入我们。

相关研究成果展示：

指导本科生科研训练：获校级本科优秀毕业论文（设计）团队（2022年）。指导国家级大创项目1项、省级大创项目1项。指导本科生发表科研论文1篇。

代表性论文：

1.Ma, A.; Deng, X.; Wei, L.; Dong, Y.; Zhang, P.; Xuan, S.;* Zhang, Z.* High Antibacterial Activity and Selectivity of Cationic Disubstituted Polypeptoids with Stable Helices and Enzymatic Resistance. ACS Appl. Mater. Interfaces 2025, 17, 27950-27963.

2.Liao, M.; Yao, Y.; Gan, K.; Su, X.; Zhao, N.; Zuckermann, R. N.; Xuan, S.;* Zhang, Z.* Self-promoted Controlled Ring-opening Polymerization via Side Chain-mediated Proton Transfer for the Synthesis of Tertiary Amine-pendant Polypeptoids. Angew. Chem. Int. Ed. 2025, 64, e202417990.

3.Liu, W.; Deng, X.; Dong, Y.; Xuan, S.;* Zhang, Z.* Controlled Synthesis of Crystalline and Helical N-Alkyl Poly(l-alanine). Macromolecules 2024, 57, 7031-7042.

4.Ma, A.; Wang, X.; Xuan, S.;* Zhang, Z.* Accelerated Heterogenous Ring-Opening Polymerization towards Well-defined Helical Poly (N-allyl alanine) with Clickable Side Chains. Sci. China Chem. 2024, 67, 2056-2062.

5.Yu, X.; Wang, Y.; Dong, Y.; Zhao, Y.; Zhang, L.; Xuan, S.;* Zhang, Z.* Efficient Synthesis of N-Methyl Polypeptides by Organic Acid Promoted Controlled Ring-Opening Polymerization of N-Methyl-α-Amino Acids N-Carboxyanhydrides. Macromolecules2023, 56, 8899-8911.

6.Ma, A.; Yu, X.; Liao, M.; Liu, W.; Xuan, S.;* Zhang, Z.*Research Progress in Polypeptoids Prepared by Controlled Ring-Opening Polymerizations. Macromol. Rapid Commun.2022, 2200301.

7.Jia, R. Tu, Y.; Glauber, M.; Huang, Z.; Xuan, S.*; Zhang, W.; Zhou, N.; Li. X.; Zhang, Z.*; Zhu, X. Fine control of the molecular weight and polymer dispersity via a latent monomeric retarder. Polym. Chem.2021, 12, 349-355.

8.Xuan, S.; Jiang, X.; Balsara, N.P.; Zuckermann, R. N.* Crystallization and self-assembly of shape-complementary sequence-defined peptoids. Polym. Chem.2021, 12, 4770-4777.

9.Zhang, L.; Song, Y.; Cao, Y.; Wang, Z.; Huang, Z.; Xuan, S.*; Zhang, Z.* A photo–thermal dual-regulated latent monomer strategy for sequence control of polymers. Polym. Chem.2021, 12, 4996-5002.

10.Xuan, S.; Zuckermann, N. R. Engineering the Atomic Structure of Sequence-defined Peptoid Polymers and Their Assemblies. Polymer, 2020, 202, 122691.

11.Xuan, S.; Zuckermann, R. N.*; Diblock Copolypeptoids: A Review of Phase Separation, Self-Assembly and Biological Applications. J. Mater. Chem. B, 2020, 8, 5380-5394.

12.Xuan, S.; Jiang, X.; Spencer, R.; Li. N. K.; Prendergast, D.; Balsara, N. P.*; Zuckermann, N. R.* Atomic-level Engineering and Imaging of Polypeptoid Crystal Lattices. Proc. Natl. Acad. Sci. 2019, 116, 22491-22499.

13.Jiang, X.†; Xuan, S.†; Kundu, J.; Prendergast, D.; Zuckermann, R. N.*; Balsara, N. P.* Effect of Processing and End Groups on the Crystal Structure of Polypeptoids Studied by Cryogenic Electron Microscopy at Atomic Length Scales. Soft Matter2019, 15, 4723-4736.

14.Xuan, S. and Vicente, M. G. H.* Recent Advances in Boron Delivery Agents for Boron Neutron Capture Therapy (BNCT). In Boron-Based Compounds: Potential and Emerging Applications in Medicine; 1st Ed.; Hey-Hawkins, E.; Teixidor, C. V., Eds. John Wiley & Sons: New York, 2018; pp 298-342.

15.Xuan, S.; Gupta, S.; Li, Xin, Bleuel, M.; Schnerider, G. J.*; Zhang, D.* Synthesis and Characterization of Well-defined PEGylated Polypeptoids as Protein-resistant Polymers. Biomacromolecules 2017, 18, 951-964.

16.Xuan, S.; Zhao, N.; Zhou, Z. Franczek, F. R.; Smith, K. M.; Vicente, M. G. H.* Synthesis and Spectroscopic Investigation of a Series of Push-Pull Boron Dipyrromethenes (BODIPYs). J. Org. Chem.2017,82, 2545-2557.

17.Xuan, S.; Lee, C. -H.; Chen, C.; Doyle, A. B.; Zhang, Y.; Li, G.; John, V. T.; Hayes, D.; Zhang, D.* Thermoreversible and Injectable ABC Polypeptoid Hydrogels: Controlling the Hydrogel Properties through Molecular Design. Chem. Mater.2016, 28, 727-737.

18.Xuan, S.; Zhao, N.; Zhou, Z.; Franczek, F. R.; Vicente, M. G. H.* Synthesis and In Vitro Studies of a Series of Carborane-containing Boron Dipyrromethanes (BODIPYs). J. Med. Chem. 2016, 59, 2109.