Acyl Radicals from α‑Keto Acids Using a Carbonyl Photocatalyst: Photoredox-Catalyzed Synthesis of Ketones
Da-Liang Zhu1, Qi Wu1, David James Young2, Hao Wang1, Zhi-Gang Ren1, and Hong-Xi Li1,*（李红喜）
1College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China
2College of Engineering, Information Technology and Environment, Charles Darwin University, Darwin, Northern Territory 0909, Australia
Org. Lett. 2020, 22, 6832--6837
Acyl radicals have been generated from α-keto acids using inexpensive and commercially available 2-chloro-thioxanthen-9-one as the photoredox catalyst under visible light illumination. These reactive species added to olefins or coupled with aryl halides via a bipyridyl-stabilized Ni(II) catalyst, enabling easy access to a diverse range of ketones. This reliable, atom-econo()mical, and eco-friendly protocol is compatible with a wide range of functional groups.
链接：https://pubs.acs.org/doi/10.1021/acs.orglett.0c02351