Sensitive and specific detection of ractopamine: An electrochemiluminescence immunosensing strategy fabricated by trimetallic Au@Pd@Pt nanoparticles and triangular gold nanosheets
Jia Chen a , Gaobiao Cheng a , Kang Wu b , Anping Deng a , ∗（邓安平）, Jianguo Li a , ∗（李建国）
aThe Key Lab of Health Chemistry & Molecular Diagnosis of Suzhou, College of Chemistry, Chemical Engineering & Materials Science, Soochow University, Suzhou 215123, PR China
bSchool of Biology & Basic Medical Science, Soochow University, Suzhou 215123, PR China
Electrochimica Acta 361 (2020) 137061
A competitive electrochemiluminescence (ECL) immunosensor has been designed for the detection of ractopamine (RAC) in the system of peroxydisulfate/oxygen (S2O82−/O2). In order to augment the signal of ECL response, trimetallic Au@Pd@Pt core-shell nanoparticles (Au@Pd@Pt NPs) was applied as catalyst and a composite co-reactant, norfloxacin−L-cysteine (NC) was coated on the surface of Au@Pd@Pt NPs to increase the performance of signal amplification. Triangular gold nanosheets (Au TNSs) was selected as the platform material to connect the antigen of RAC since the ultra-thin two-dimensional structure could reduce the barrier effect of electrode modification materials on the process of electron transfer. Consequently, the proposed immunosensor performed ideal detection sensitivity (0.03 pg mL−1) for RAC with a wide linear range from 0.0001 to 1000 ng mL−1.
链接：https://www.sciencedirect.com/science/article/pii/S0013468620314547