Cobalt(II)-Catalyzed Synthesis of Sulfonyl GuanidinesviaNitrene Radical Coupling with Isonitriles: A Combined Experimental and Computational Study
Zheng-Yang Gu,Yuan Liu,Fei Wang,Xiaoguang Bao*（鲍晓光）,Shun-Yi Wang*（汪顺义）,and Shun-Jun Ji*（纪顺俊）
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, China.
ACS Catalysis2017,7, 3893--3899.
A Co(II)-catalyzed synthesis of sulfonyl guanidines by using amines, isonitriles, and organic azides as nitrene sources has been developed. This protocol provides an environmentally friendly and simple strategy for the synthesis of sulfonyl guanidine derivatives by employing a range of substrates and will find potential applications in organic synthesis. The computational and EPR studies suggested the formation of guanidine derivatives via a cobalt–nitrene radical intermediate.
链接：http://pubs.acs.org/doi/abs/10.1021/acscatal.7b00798