A trisulfur radical anion (S3 ) involved sulfur insertion reaction of 1,3-enynes: sulfide sources control chemoselective synthesis of 2,3,5-trisubstituted thiophenes and 3-thienyl disulfides
Jing-Hao Li a, Qi Huang a, Weidong Rao b, Shun-Yi Wang *a （汪顺义）and Shun-Jun Ji *a（纪顺俊）
a Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, 215123, P. R. China.
b Jiangsu Key Laboratory of Biomass-based Green Fuels and Chemicals, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China
Chem. Commun., 2019, 55, 7808--7811
Cascade cyclization reactions of S3˙−in situ generated from S2− with 1,3-enynes for the chemoselective synthesis of 2,3,5-trisubstituted thiophenes and 3-thienyl disulfides controlled by sulfide salts are developed. These two protocols provide new, environment-friendly and simple strategies to construct 2,3,5-trisubstituted thiophenes and 3-thienyl disulfides via the formation of two and six C–S bonds, respectively.
链接：https://pubs.rsc.org/en/content/articlelanding/2019/CC/C9CC03604K#!divAbstract