张正彪教授在 Angew. Chem. Int. Ed. 发表研究论文

Combining Orthogonal Chain-End Deprotections and Thiol–Maleimide Michael Coupling: Engineering Discrete Oligomers by an Iterative Growth Strategy

Zhihao Huang¹, Junfei Zhao¹, Zimu Wang¹, Fanying Meng¹, Kunshan Ding¹, Xiangqiang Pan¹, Nianchen Zhou¹, Xiaopeng Li², Zhengbiao Zhang^*1（张正彪）, and Xiulin Zhu¹

¹State and Local Joint Engineering Laboratory for Novel Functional

Polymeric Materials, Jiangsu Key Laboratory of Advanced Functional

Polymer Design and Application, College of Chemistry

Chemical Engineering and Materials Science, Soochow University

Suzhou, 215123 (China)

²Department of Chemistry, University of South Florida, Tampa

Florida, 33620 (USA)

Angew. Chem. Int. Ed. 2017, 56, 13612 --13617

Orthogonal maleimide and thiol deprotections were combined with thiol–maleimide coupling to synthesize discrete oligomers/macromolecules on a gram scale with molecular weights up to 27.4 kDa (128mer, 7.9 g) using an iterative exponential growth strategy with a degree of polymerization (DP) of 2ⁿ−1. Using the same chemistry, a “readable” sequence-defined oligomer and a discrete cyclic topology were also created. Furthermore, uniform dendrons were fabricated using sequential growth (DP=2ⁿ−1) or double exponential dendrimer growth approaches (DP=22n −1) with significantly accelerated growth rates. A versatile, efficient, and metal-free method for construction of discrete oligomers with tailored structures and a high growth rate would greatly facilitate research into the structure–property relationships of sophisticated polymeric materials.

链接：http://onlinelibrary.wiley.com/doi/10.1002/anie.201706522/abstract