Electrochemiluminescence resonance energy transfer system between nontoxic SnS2 quantum dots and ultrathin Ag@Au nanosheets for chloramphenicol detection

Jia Chen, Jieru Zheng, Kang Zhao, Anping Deng^*（邓安平）, Jianguo Li^*（李建国）

The Key Lab of Health Chemistry & Molecular Diagnosis of Suzhou, College of Chemistry, Chemical Engineering & Materials Science, Soochow University, Suzhou 215123, China

Chemical Engineering Journal 392 (2020) 123670

Herein, an efficient electrochemiluminescence energy resonance transfer (ECL-RET) system was first applied in an immunosensor for the detection of chloramphenicol (CAP). SnS₂ quantum dots (SnS₂ QDs) has an extremely narrow electrochemical emission spectrum, which was used as donor. Compared with conventional quantum dots, toxic-element-free SnS₂ QDs exhibit superior environmental friendliness and biocompatibility. Ultrathin Ag@Au nanosheets (Ag@Au NSs) was selected as acceptor due to its excellent structure and controllable UV-vis absorption range. Furthermore, ZnO nanoflowers (ZnO NFs) was employed to modify the electrode surface to provide stable luminescent environment and support more SnS₂ QDs. Taking these advantages, the absorption spectra of Ag@Au NSs and the ECL emission spectra of SnS₂ QDs are highly matched which ensures the occurrence of ECL-RET. When the CAP analyte were absent, Ag@Au NSs was immobilized on the electrode, and its ultrathin thickness effectively shortens the path of ECL-RET to produce the weak ECL intensity. Inversely, CAP analyte would compete with coating antigen for the certain amount of antibody to remove excess Ag@Au NSs and cause relatively high ECL intensity. As a result, the proposed immunosensor performed satisfactory sensitivity with a wide linear range from 0.005 to 1000 ng mL⁻¹ and a low detection limit (1.7 pg mL⁻¹).

链接：https://www.sciencedirect.com/science/article/pii/S1385894719330852