报告题目: Smart Polymer Applications in Drug Delivery andDiagnostics
Department of Bioengineering, Universityof Washington, Seattle, USA
报告时间: 2016年3月21日（星期一）上午9:30-10:30
报告地点: 独墅湖校区907号楼1445室
报告摘要: In the first part of my talk I will describeour application of smart T- and pH-responsive polymers for point-of-careimmunoassays. In this work, we havesynthesized smart polymers using RAFT polymerization techniques, and conjugatedthem to: a) capture antibodies, b) porous membrane surfaces, c) magnetic and d)gold nanoparticles. We have also coated the smart polymer-antibody conjugateson magnetic and gold nanoparticles. These smart polymer systems are used tocapture and concentrate the target, biomarker molecules and then release themas a concentrated pulse for downstream assay.
In thesecond part of my talk I will describe our work with smart polymer carriers forintracellular delivery of biomolecular drugs. Such drugs include peptides,proteins and nucleic acid drugs (eg, pDNA and siRNA). Many of these drugs actat intracellular sites; however, the effective intracellular delivery of these“fragile” drugs remains a significant challenge. Endocytosis of drugformulations usually results in localization within the endosome, where thepredominant fate is fusion with lysosomes and enzymatic degradation of thebiomolecular drug. Inspired by the principles behind the ability of manyviruses to deliver their genomic cargo from the endosome to the cytosol, wehave designed and synthesized a family of biomimetic, “smart” acid-responsivepolymeric carriers that can enhance the escape of fragile biomolecular drugsfrom the endosome to the cytosol.
报告人简介：Professor Hoffman studied at M.I.T., where hereceived B.S., M.S., and Sc.D. degrees in Chemical Engineering between 1949 and1957. He taught on the faculty of the M.I.T. Chemical Engineering Departmentfor a total of ten years. Since 1970 he has been Professor of Bioengineering atthe University of Washington in Seattle. He continues to actively teach andadvise on research in the areas of smart polymers and hydrogels, drug delivery,separations, and biomaterial surface modification. Some of his professionalactivities, recognitions and awards have included:
• President, Society forBiomaterials (1983-1984)
• Biomaterials SciencePrize, Japanese Biomaterials Society (1990)
• Founders’ Award of theSociety for Biomaterials (2000)
• Chandra Sharma Award,Biomaterials Society of India (2003)
• Elected to the NationalAcademy of Engineering (2005)
• InternationalRecognition Award, Society for Polymer Science, Japan (2006)
• Founders’ Award of theControlled Release Society (2007)
• International symposia havebeen organized in Maui, Hawaii in honor of his 60th (1992), 70th (2002), and 80th (2012) birthdays.
• “Hoffman Family”symposia (HFS) have been organized by the National Institute of Materials Science(NIMS) in Tsukuba, Japan in 2010 and 2014, and by Chonnam University inGwangju, Korea in 2015. A fourth HFS is planned for Sept. 2016 in Taipei,Taiwan.
1. G.H. Chen, and A.S.Hoffman, Nature 373 (1995) 49-52.
2. P.S. Stayton, T. Shimoboji, C. Long, A. Chilkoti, G.Chen, J.M. Harris and A.S. Hoffman, Nature 378 (1995) 472-474.
3. Z. Ding, R.B. Fong, C.J. Long, A.S. Hoffman, and P.S. Stayton, Nature 411 (2001) 59-62.
4. A.S. Hoffman, Adv. Drug Del. Revs, 43 (2002) 3-12.
5. R Namgung, YM Lee, J Kim, Y Jang, BH Lee, IS Kim, PSokkar, YM Rhee, AS Hoffman and WJKim, Nature Comm. 5:3702 (2014).
(报告联系人：钟志远老师课题组）