报告题目: Polymers at Synthetic and Biological Surfaces
- from autonomous systems to cell-basedtherapy -
报告人: Prof. Harm-Anton Klok
Institutesof Materials and Chemical Sciences and Engineering
Ecole Polytechnique Fédérale de Lausanne(EPFL), Lausanne, Switzerland
报告时间: 2016年3月22日（星期二）下午2:00-3:00
报告地点: 独墅湖校区909号楼3403室
报告摘要: Grafting polymers from or onto surfacesprovides manifold opportunities to modulate the properties of and addfunctionality to both synthetic and biological surfaces and interfaces. Thefirst part of this presentation will discuss the possibilities that areprovided by surface-initiated controlled radical polymerization to generate“polymer brush” modified surfaces. Surface-initiated polymerization techniquesare attractive as they allow precise control over the conformation of thesurface-grafted polymer chains, which in turns dictates properties such as thenon-fouling behavior or biomolecule binding capacity of these thin films.Moreover, it has also been recently shown that the stretched chain conformationof densely grafted polymer brush films can impact the reactivity of thesurface-grafted polymer chains, which could pave the way towards novelresponsive surfaces and interfaces. The second part of this presentation willdiscuss the modification of biological surfaces, more specifically the membraneof living cells with synthetic polymers. Engineering living cells withsynthetic polymers is attractive for cell based therapies. Chemicalmodification of cell surfaces, in contrast to synthetic surfaces, ischallenging from a chemistry point of view, since they are fluid and dynamicand since chemistries are required that do not impart the viability andfunctionality of the cells. Results from preliminary experiments will bediscussed in which living cells have been decorated with model polymernanoparticles.
报告人简介：Harm-Anton Klok is Full Professor at theInstitutes of Materials and Chemical Sciences and Engineering at the EcolePolytechnique Fédérale de Lausanne (EPFL) (Lausanne, Switzerland). His researchinterests include polymer nanomedicine as well as polymer surface and interfacescience.
He studied chemical technology at theUniversity of Twente (Enschede, The Netherlands) from 1989 to 1993 and receivedhis Ph.D. in 1997 from the University of Ulm (Germany) after working withMartin Möller. After postdoctoral research with David N. Reinhoudt (Universityof Twente) and Samuel I. Stupp (University of Illinois at Urbana–Champaign,USA), he joined the Max Planck Institute for Polymer Research (Mainz, Germany)in early 1999 as a project leader in the group of Klaus Müllen. In November2002, he was appointed to the faculty of EPFL. Since 2012 he is Director of theInstitute of Materials (~ Department Head) and also directs the Molecular andHybrid Materials Characterization Center at EPFL.
Harm-Anton Klok is recipient of the ArthurK. Doolittle Award of the American Chemical Society (2007) and is AssociateEditor of the American Chemical Society journal Biomacromolecules and serves orhas served on the editorial advisory board of Eur. Polym. J., J. Polym. Sci. A:Polym. Chem., Macromolecules, ACS Macro Letters as well as Macromol. RapidCommun., Macromol. Bioscience and Chimia. He has been a Visiting Professor atthe University of Bordeaux (France) and the University of Massachusetts/Amherst(USA), is a Chair Professor at the College of Chemistry, Chemical Engineering andMaterials Science, Soochow University (Suzhou, China), guest professor at theChangchun Institute of Applied Chemistry, Chinese Academy of Sciences(Changchun, China), at the School of Environmental and Chemical Engineering,Shanghai University (Shanghai, China) and at the School of Materials Scienceand Engineering, Nanyang Technological University, Singapore and was awarded aChinese Academy of Sciences visiting professorship for senior internationalscientists (Institute of Chemistry, Chinese Academy of Sciences, Beijing).
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