题目：Nanoscopic vibrations of bacteria adhering to surfaces and theirrelevance for adhesion and detachment
报告人：Prof. dr. Henny C. van der Mei，University Medical Center Groningen
报告时间：2016年4月19日（星期二）上午10:00-11:00
报告地点：独墅湖校区907号楼1445室
Abstract: Bacteria adhering to surfacesdemonstrate nanoscopic vibrations around their equilibrium positions that haveremained unnoticed for decades. Vibrational amplitudes of adhering bacteriawere highest in low ionic strength suspensions. Under fluid flow, amplitudeswere lower in the direction of flow than perpendicular to it, becausestretching of cell surface polymers by the flow causes stiffening of thepolyelectrolyte network surrounding a bacterium. Often bacteria do not adhereto bare surfaces but to adsorbed protein films. Vibrations amplitudes aredepended on the softness of these protein films. Vibration amplitudes allowcalculation of the spring constants of the bond with which bacteria adhere to asurface which will be related to electrophoretic softness of the bacterial cellsurface and which can be related to bacterial adhesion and detachment of thebacteria from the surface.
报告人简介：
Currentposition
Fullprofessor at the Department of Biomedical Engineering, University MedicalCenter Groningen and University of Groningen, Groningen, The Netherlands.
Assitanteditor Biofouling.
Editorfor protocols Collids and Surfaces B: Biointerfaces
Editorialboard Colloids and Surfaces B: Biointerfaces
Editorialboard Journal of Biomedicine and Biotechnology
THESES,SUPERVISED
>70theses supervised with subjects varying from mouthrinses, contact lenses,biofilm formation on hip prostheses to polymer brushes, mechanisms of microbialadhesion and co-cultures of mammalian cells and bacteria.
PUBLICATIONS
FULLPAPERS in peer reviewed journals > 500
Bookchapters: 37
Researchinterest:
Mechanismsof microbial adhesion in relation with biomaterial associated infections.
Racefor the surface between tissue cells, immune cells and microorganisms.
Modificationof biomaterials in order to avoid biomaterials associated infections.
Web-of-ScienceSummary (January 2016):
Numberof articles, short notes, reviews and proceedings in English 469
Totalnumber of citations 14148
Averagenumber of citations per paper 30.17
H-factor60
Most recent papers in journals with impact factor> 10 (per January 2016):
IF21.2: Microbiotarestoration: natural and supplemented recovery of human microbial communities.NATURE REVIEWS MICROBIOLOGY 9(2011)27-38.
IF10.7: Biomaterialsassociated infection: Locating the finish line in the race for the surface.SCIENCE TRANSLATIONAL MEDICINE 4(2012) DOI: 10.1126/scitranslmed.3004528.
IF17.3: Transmissionof infection by flexible gastrointestinal endoscopy and bronchoscopy. CLINICALMICROBIOLOGY REVIEWS 26(2013)231-254.
IF14.8: Recombinantsupercharged polypeptides restore and improve biolubrication. ADVANCEDMATERIALS 25(2013)3426-3431.
IF12.0: Nanoscopicvibrations of bacteria with different cell-wall properties adhering to surfacesunder flow and static conditions. ACS Nano 8(2014)8457-8467.
IF11.8: 3D-printableantimicrobial composite resins. ADVANCED FUNCTIONAL MATERIALS25(2015)6756-6767.
IF 13.2: Viscoelasticityof biofilms and their recalcitrance to mechanical and chemical challenges. FEMSMICROBIOLOGY REVIEWS 39(2015)234-245.
Fivehighest cited papers (per January 2016)
551x: Physico-chemistryof initial microbial adhesive interactions - its mechanisms and methods forstudy. FEMS MICROBIOLOGY REVIEWS 23(1999)179-230.
433x: Measurementof the surface free-energy of bacterial-cell surfaces and its relevance foradhesion. APPLIED AND ENVIRONMENTAL MICROBIOLOGY 48(1984)980-983.
211x: Invitro and in vivo antimicrobial activity of covalently coupled quaternaryammonium silane coatings on silicone rubber. BIOMATERIALS 23(2002)1417-1423.
199x:Bacterial adhesion to surface hydrophilic and hydrophobic contact lenses.BIOMATERIALS 22(2001)3217-3224.
184x: How a fungus escapes the waterto grow into air. CURRENT BIOLOGY 9(1999)85-88.
(报告联系人：陈红老师课题组）