报告题目: Nylon-3 Polymers asEmerging Biomaterials

报告人：Runhui Liu (刘润辉)

(School of Materials Science and Engineering EastChina University of Science and Technology)

报告时间：2016年06月16日（周四）上午9:00

报告地点：独墅湖校区907号楼1445学术报告室

欢迎广大师生踊跃参加

报告摘要：

Naturalproteins/peptides are widely used in biomedical applications, but are stillsuffered from their susceptibility to proteolysis, high price and difficulty inlarge-scale synthesis. Nylon-3 polymers (poly-β-peptides) have a poly-amide backbone that issimilar to that of natural proteins/peptides. Therefore, nylon-3 is likely tobe biocompatible as emerging biomaterials.

We studied nylon-3 assynthetic mimics of Host defense peptides (HDP). These nylon-3 copolymers are normallycomposed of a hydrophilic/cationic subunit and a hydrophobic subunit to mimictwo key characteristics of HDP, net positive charge and amphiphilicity. Nylon-3polymers display potent and broad-spectrum activity against multiple bacterialspecies, including methicillin-resistant S.aurues (MRSA) andvancomycin-resistant E. faecium (VREF), as well as low hemolytic activity and and cytotoxic.Moreover, neither E. coli nor MRSA developed resistance toward nylon-3after repeated treatment. We are also surprised to discover nylon-3polymers with potent and selective activity against multiple strains of C. albicans, the most common pathogenicfungus in humans. In addition to activity against planktonic fungal cells,nylon-3 also inhibits the formation of C.albicans biofilms and is active against mature C. albicans biofilms.

Nylon-3 can also mimicthe function of ECM proteins/peptides to have cell-adhesive functions. The bestnylon-3 support cell adhesion even better than the gold-standard RGD peptide.The cell-adhesion of nylon-3 was found to be mediated by proteins. Furtherstudy discovered that nylon-3 can selectively support the growth of onlyendothelial cells rather than smooth muscle cells and fibroblast cells. Themechanism of nylon-3’ cell-selectivity was different from that of the ECMproteins/peptides. The structural diversity, high stability and easypreparation of nylon-3 polymers suggest that members of this class may prove tobe useful biomaterials in the future.

刘润辉教授简历：

1997/09–2004/06，华东理工大学，（原）化学与制药学院，学士、硕士

2004/08–2009/08，Purdue University（普渡大学），化学系，博士

2009/09-2010/03，California Institute of Technology（加州理工学院)，博士后

2010/04-2014/12，University of Wisconsin–Madison (威斯康星大学-麦迪逊校区)，博士后

2014/12-至今，华东理工大学，材料科学与工程学院，教授

荣誉：

2014/08 华东理工大学特聘教授

2014/09 “东方学者”上海市高校特聘教授

2015/05 中组部“青年千人”

（报告联系人：陈红老师课题组）