报告题目: Formulation andDelivery of Biopharmaceutical Drugs
报告人: Prof. Yong-Hee Kim
Department of Bioengineering, HanyangUniversity, Seoul, Korea
报告时间: 2016年7月19日（星期二）上午10:30-11:30
报告地点: 独墅湖校区909号楼3403室
报告摘要: Pharmaceutical Biotechnology is an increasingly importantarea of science and technology, contributing to design and delivery of newtherapeutic drugs, the development of diagnostic agents for medical tests, andthe beginnings of gene therapy for correcting the medical symptoms of hereditarydiseases. The biotech industry is now 39-year-old. A steady stream oftherapeutic agents has not only opened up new ways of treating untreatablediseases but also contributed much to our understanding of human biology.
Althoughrecent progress in biotechnology enables production of various protein drugsfor therapeutic purposes, several challenges still remain, including enzymaticsusceptibility, stability during storage, and efficacy after administrationinto the body. Direct application of protein by itself as therapeutic agent hassome holdbacks due to their rapid elimination from the circulation due to renalfiltration and enzymatic degradation, danger in triggering an immune response,and widespread distribution into non-targeted organs and tissues. Thesedrawbacks can be overcome with polymeric drug delivery systems such aspegylation, nano- or micro-particular drug delivery systems or in situ forminggels to achieve the controlled protein drug release, systemically or locally,over a long period of time. At present, poly (ethylene glycol) (PEG) has beenwidely used in the field of drug delivery system. This polymer is watersoluble, has no electric charge, and is nonimmunogenic and nontoxic. Colloidalcarrier / nanoparticles carrier systems have been drawn much attention latelyas drug delivery carriers due to their high loading capacity as well as theprotective characteristic towards the bioactive compounds against proteindegradation. In situ gels can solve the problems associated with most widely usedbiodegradable microsphere formulations, such as the drug loss caused by lowencapsulation efficiencies of microspheres, the use of harsh organic solventand manufacturing costs increases by several processes.
报告人简介：Dr. Yong-Hee Kim graduated from the College of Pharmacy, Seoul NationalUniversity, Korea in 1983 and received his M.S in the Physical Pharmacy Lab.,College of Pharmacy, Seoul National University, Korea in 1985 (advisor: Prof.Byung Sul Yu). He received Ph.D. in the Department of Pharmaceutics andPharmaceutical Chemistry, University of Utah, U.S.A. in 1992 (advisor: Prof.William I. Higuchi) followed by Post-Doctoral fellow for 2 years in Prof. SungWan Kim’s lab at the University of Utah.
His current professional activities areProfessor in the Department of Bioengineering and Director of the Institute forBioengineering and Biopharmaceutical Research(IBBR) at the Hanyang University,Adjunct Professor of the College of Chemistry and Chemical Engineering, SoochowUniversity in China, Research Professor of the Center for Controlled ChemicalDelivery, Department of Pharmaceutics and Pharmaceutical Chemistry, Universityof Utah in USA and Evaluation Committee of the Korea Food and DrugAdministration.
His scientific activities are Editor ofthe Archives of Pharmacal Research, International Committee of the Symposium onInnovative Polymers for Controlled Delivery, Secretary general of theBioTherapeuics Delivery Society and Vice-Chairman of the Korean Society forBiomaterials. He also served as an Executive Director of the Korean Society forBiomaterials, Secretary General of the 3rd Asian Pharmaceutical Congress,General Executive of the Korean Society for Biomaterials, Chairman of PlanningCommittee and General Executive of the Korean Society of PharmaceuticalSciences and Technology.
His research interests are focused onmainly drug delivery systems such as biopharmaceutical delivery, non-viral genedelivery (plasmid DNA, siRNA, ODN), fusion protein delivery, injectablehydrogels, biomedical polymers and combination therapy.
He received ‘Scientist of the Month’Award from the Ministry of Science, ICT and Future Planning, Korea in 2015,‘R&D Distinguished Idea’ Award, Hanyang University, Korea in 2015,‘Scientist of the Month’ Award, Hanyang University, Korea in 2015, ‘OutstandingScientist’ Award, Yangyoung Foundation, Korea in 2013, ‘Power Brain’ Award,Sisa Magazine, Korea in 2012 and ‘Most Cited Paper’ Award from the Journal ofControlled Release in 2005.
(报告联系人：钟志远老师课题组）