题目：Tough Materials Through a Click Chemistry Approach
报告人：Prof. ANDREW P. DOVE
Department of Chemistry, University of Warwick, Coventry,CV4 7AL, UK
地点：907楼1445房间
时间：2016年9月21日(周三 ) 9:30-10:30
摘要：
Thedevelopment of novel degradable biomaterials is largely restricted by thepaucity of well-defined functional degradable polymers with which to accessmaterials with useful properties. As such, one focus of our research is toinvestigate methodologies that can be used to access new materials that areable to be specifically tailored to a range of applications. To this end, weare interested in designing and synthesizing materials in which many of thestarting materials are derived from sustainable resources using novel catalystsystems and applying metal-free ‘click’ chemistries.
Our syntheticapproaches allow for the development of materials with properties that are hardto obtain by other methods. We are focussed on understanding and controllingthe properties of our materials on all length scales. From the development ofnew materials with precisely tailored macroscopic mechanical and degradativeproperties as well as biological interactions, to the 3-dimensional control ofstructure at the micron-scale as well as the controlled nanoscale assembly toprovide novel materials, hydrogels (see picture), scaffolds and nanoparticlesfor tissue engineering, regenerative medicine and drug/gene deliveryapplications.
Thispresentation will focus on recent work that has been directed towards the synthesisand study of novel degradable, tough hydrogel materials.
BIOGRAPHY
Andrew P. Dove is currently a Professor ofChemistry at the University of Warwick. Prof. Dove performed his Ph.D. studiesat Imperial College London, under the supervision of Prof. Vernon C. GibsonF.R.S. His experience was subsequently extended by postdoctoral positions atStanford University and IBM, both in the USA. In 2005 Prof Dove returned to theUK as an RCUK Academic Fellow before being promoted to Assistant Professor ofChemistry in 2006, Associate Professor in 2009 and Full Professor in 2014. Hecurrently also holds an adjunct professor position at Monash University inAustralia, a Royal Society Industry Fellowship and a prestigious ERCconsolidator award. The Dove group is primarily focussed on the design,synthesis and application of novel biodegradable polymers for applications asvaried as sustainable packaging and tissue engineering. Research in the groupencompasses the development of new catalytic methods for polymer synthesis,application of renewable resources in polymer synthesis, development of facilesynthetic routes to multi-functional degradable polymers, control of polymerself-assembly for novel drug-delivery vectors and application of hydrogels and3-dimensionally controlled materials in regenerative medicine. Prof. Dove iscurrently on the editorial advisory board of RSC Biomaterials Science,Macromolecules and ACS Macro Letters and is a fellow of the Royal Society ofChemistry. He was awarded the Macro Group UK Young Researcher Medal in 2009,the RSC Gibson-Fawcett Award in 2014 and the 2016Biomacromolecules/Macromolecules Young Investigator Award.
SelectedPublications：
[1] Independent Control of Elastomer Propertiesthrough Stereocontrolled Synthesis. Bell. C. A.; Yu, J.; Barker, I. A.; Truong,V. X.; Cao, Z.; Dobrinyin, A. V.; Becker, M. L.; Dove, A. P. Angew. Chem. Int.Ed. (2016). DOI: 10.1002/anie.201606750R1
[2] Simultaneous orthogonal dual-click approachto tough, in situ-forming hydrogels for cell encapsulation. J. Am. Chem. Soc.(2015) 137, 1618 - 1622.
[3] Organocatalytic, Regioselective Nucleophilic“Click” Addition of Thiols to Propiolic Acid Esters for Polymer–PolymerCoupling Angew. Chem. Int. Ed. (2013), 52, 4132 – 41
（报告联系人：张正彪老师）