题目：Dithiomaleimides and Monoaminomaleimides: New functional handles inpolymer science

报告人：Prof. RACHEL K.O’REILLY

Department of Chemistry, University of Warwick, Coventry,CV4 7AL, UK

地点：907楼1445房间

时间：2016年9月21日(周三 ) 8:30-9:30

摘要：

Dithiomaleimides (DTMs) andmonoaminomaleimides (MAMs) with alkyl substituents are shown to be a novelclass of highly emissive and stable fluorophores. Variable solubility andfurther functionalization of this unit can easily be tailored through thechoice of N and S substituents. Furthermore, inclusion of a DTM or MAM unitinto a polymerization initiator or insertion into the disulfide bond ofproteins demonstrates the utility for fluorescent labeling [1,2].  A key advantage of this new reporter group (Fig. 1) is its versatile chemistry andits notably small size, which allows for ready incorporation without affectingor disrupting the self-assembly process. This is critical to the formation ofcore-shell polymeric contrast and drug delivery agents and enables the faciletracking of the nanostructure. We demonstrate the potential of thisfunctionality through incorporation into a range of polymerization systems,which can be tailored to undergo assembly and when in the assembled state, doesnot self-quench [3]. The further exploration of this functional group as ahandle in a range of polymeric materials will be discussed [4,5].

 Figure1. Structure of the DTM group

BIOGRAPHY

Rachel O’Reilly is a Professor of Polymer Chemistry andan ERC consolidator grant holder at the University of Warwick. Since startingher independent career in 2005 she has raised around £8 million in research funding (from EPSRC, RoyalSociety, EU, industry) and currently leads a group of 21 members and undertakesworld renowned research in the fabrication of polymer nanostructures usingadvances in self-assembly. She also leads projects in the area of catalysis,responsive polymers, nanostructure characterization and DNA nanomaterials. Shehas published over 150 papers to date, with three quarters in journals withimpact factors > 5. She has been awarded 6 highly competitive youngscientist medals, including in 2012 the RSC Hickinbottom medal andIUPAC-Samsung young polymer scientist award (she was the first female winner ofthis global award), and in 2013 the first non-American winner of the AmericanChemical Society Mark Young Polymer Scientist award. In 2016 she was awardedthe Gibson-Fawcett Award from the RSC in recognition of her innovative researchin materials science.

SelectedPublications：

[1]M.P. Robin, P. Wilson, A.B. Mabire, J.K. Kiviaho, J.E. Raymond, D.M. Haddleton,R.K. O’Reilly, J. Am. Chem. Soc. 2013, 135, 2875-2878.

[2]M.P. Robin and R.K. O’Reilly, Chem. Sci. 2014, 5, 2717-2723.

[3]M.P. Robin, A.B. Mabire, J. Damborsky, E. Thom, U. Winzer-Serhan, J. Raymond,R.K. O'Reilly, J. Am. Chem. Soc., 2013, 135, 9518–9524.

[4]A. B. Mabire, M. P. Robin, W.-D. Quan, H. Willcock, V. G. Stavros, R. K.O’Reilly, Chem. Commun, 2015, 51, 9733-9736.

[5]A. B. Mabire, Q. Brouard, A. Pitto-Barry, R. J. Williams, H. Willcock, N.Kirby, E. Chapman, R. K. O'Reilly, Polym. Chem.,2016, DOI: 10.1039/C6PY01254J.

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