学术报告：Engineered Nano and MicroComposite Particles for Improved Pharmaceutical Products
报告人：Rajesh N. Davé （Distinguished Professor of Chemical, Biological and PharmaceuticalEngineering, New Jersey Center for Engineered Particulates, New JerseyInstitute of Technology, Newark, NJ, 07102, USA dave@njit.edu）
报告时间：2016年9月24日（周六）下午2:00-3:00
报告地点：材化部911楼401 房间
Abstract
Research innovations applicable topharmaceutical industry as part of a multi-university, National ScienceFoundation funded Engineering Research Center (ERC) are presented. Our workfocuses on particle engineering that exploits interactions at the nano andmicro scales to innovate pharmaceutical products. The presentation will give anoverview of the research in two important areas: (1) improved bioavailabilityof poorly water soluble drugs, including a versatile nano-micro particleembedded strip-film based platform, and (2) overcoming the difficulties inprocessing pharmaceutical materials due to their high cohesion. Novelpharmaceutical solid dosage platforms for immediate release from crystallinenano and micro drug particles are discussed with a main objective of enhancingthe dissolution rate of poorly water-soluble drugs. A potentially continuousprocessing platform where drug particles are well-dispersed within ediblepolymer strip-films, is introduced. Other approach for bioavailability enhancementconsists of spray coating via fluid-bed drying of nano/micro drug suspensionsto produce high drug loaded free-flowing powders for incorporation in totablets or capsules. Next, dry coating based surface modification as apredictive, model-based approach is presented to mitigate problems posed byfine powders due to high cohesion, leading to improvements in flow,fluidization, dispersion, and bulk density. A bulk property based 2-D phase-mapis proposed to help make manufacturing decisions regarding the formulationstrategy for solid pharmaceutical dosages, presenting a promising potential forcommercial applications and costs reduction.
Keywords: Pharmaceutical Formulations;Bioavailability; Dry Coating; Strip-films; Fluid-Bed Processing and Spray Drying
Bio:Prof. Rajesh Davé is currently aDistinguished Professor in the Department of Chemical, Biological andPharmaceutical Engineering, at New Jersey Institute of Technology. He is thefounding Director of the R&D Excellence Center, New Jersey Center forEngineered Particulates, focusing on research and innovations in particleengineering for improved particle properties for applications topharmaceutical, food, electronics, and energy industries. His current researchexpertise includes engineered particulates with special emphasis onpharmaceuticals products. His research contributions include 145 journalpapers, numerous invited/keynote presentations as well as ten issued and dozenpending patents. He has also received numerous awards, most recently, 2015AIChE PTF Lectureship Award in Fluidization. He has also been engaged intechnology development and transfer activities in film coating of very fineparticles, bioavailability enhancement, and taste-masking. He has granted 28PhDs to students at NJIT, six of those are currently in US academia.
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