题目: Design of Functional Micelles for Drug Delivery
报告人：Prof. Martina Stenzel，University of NewSouth Wales
报告时间：2016年9月23日（星期五）下午 3：30
报告地点： 独墅湖校区907号楼1445室
Micelles and vesicles have long beenproposed as carriers for low molecular weight molecules including drugs. Latestdevelopments in polymer synthesis allow the design of well-controlledarchitectures. In particular living radical polymerization such as RAFTpolymerization enable the high throughput of large polymer libraries.1 However, synthetic polymers alone cannotprovide the specificity and bioactivity of nature’s building blocks such ascarbohydrates and protein. In this presentation, we discuss all the aspectsthat determine the interaction of micelles with mammalian cells includingparameters such as the shape of the nanoparticles and the surface chemistry. Wewill focus in particular on materials that were created based on glycopolymersor albumin as the outer shell.
1. Gregory,A.; Stenzel, M. H., Complex polymer architectures via RAFT polymerization: Fromfundamental process to extending the scope using click chemistry and nature'sbuilding blocks. Prog. Polym. Sci. 2012, 37 (1), 38-105.
Martina Stenzel
MartinaStenzel studied chemistry at the University of Bayreuth, Germany, beforecompleting her PhD in 1999 at the Institute of Applied MacromolecularChemistry, University of Stuttgart, Germany. She started as a postdoctoralfellow at UNSW in 1999 and is now a full Professor in the school of chemistryas well as co-director of the Centre for Advanced Macromolecular Design (CAMD)
Herresearch interest is focused on the synthesis of functional nanoparticles fordrug delivery applications. Martina Stenzel published more than 230 peerreviewed papers mainly on polymer and nanoparticle design.
She is scientific editor of MaterialsHorizons and serves currently on a range of editorial boards. She received arange of awards including the 2011 Le Fèvre Memorial Prize of the AustralianAcademy of Science.
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