报告题目： Phosphines and Phosphinocatalysis

报告人：Ohyun Kwon 教授

               Universityof California, Los Angeles

报告时间：2016年9月26日（星期一）上午 10:00 -- 11:30

报告地点：苏州大学独墅湖校区701号楼B501室

报告摘要：

Softnucleophilic phosphinocatalysis has been known since the 1960s as a result ofthe pioneering work of Horner, Price, Rauhut−Currier, and Morita. In the 1990s,Trost and Lu made important discoveries, reporting isomerization, umpolungaddition, and [3+2] cycloaddition. Nonetheless, it was not until the 2000s thatthe area of hosphinocatalysis began to flourish. My group, through carefulanalysis of the mechanism of the phosphinocatalysis reactions, has demonstratedover two dozen new reactions facilitated by phosphine catalysts. The resultsare a one-step conversion of simple acyclic starting materials into variouscarbo- and heterocycles. The practical values of these one-stepphosphine-catalyzed annulation processes are significant since (1) they areatom economic and environmentally friendly, and (2) the heterocycles are animmense class of organic compounds with numerous practical applications. Onerecent, particularly significant advancement is the creation of chiralphosphines that are derived from a natural amino acid, L-hydroxyproline. Theirsynthetic utility in the phosphine catalyzed annulations, application in totalsyntheses of (+)-ibophyllidine and (–)-actinophyllic acid, andcommercialization will also be discussed.

Ohyun Kwon教授简介:

Ohyun Kwonreceived her BS and MS in chemistry (with Eun Lee) from Seoul NationalUniversity in 1991 and 1993, respectively. She came to the US in 1993 andobtained her PhD (with Samuel J. Danishefsky) from Columbia University in 1998.After a postdoctoral stint in the laboratory of Stuart L. Schreiber at HarvardUniversity, she began her independent career in 2001 as an Assistant Professorat the University of California, Los Angeles (UCLA). In 2008, she was promotedto Associate Professor with tenure at UCLA and Full Professor in 2013. Herresearch involves the chemistry of nitrodienes, the development of chiralphosphines, phosphine-mediated and -catalyzed reactions and their applicationto natural product synthesis and chemical biology.

                                                                                                              （报告联系人：姚英明老师）