报告题目：Design of Functional Polymers for Therapeutic Applications
报告人：Cyrille Boyer
a-Centre for Advanced Macromolecular Design (CAMD), School of Chemical Engineering, UNSW Australia, Sydney, NSW 2052, Australia
b- Australian Centre for NanoMedicine, School of Chemical Engineering, UNSW Australia, Sydney, NSW 2052, Australia
报告时间：2017年4月17日（周一）上午9:30
报告地点：苏州大学独墅湖校区一期907号楼1445
Abstract:
This talk will have two parts. In the first part of this talk, we will present a light regulated polymerization. The emergence of efficient photocatalysts using transition metals, such as iridium and ruthenium, has been recently applied to perform organic reactions under visible light. Such catalysts have been utilized to perform complex organic reaction. In this talk, we present our recent results showing that these catalysts can be employed in polymer synthesis for the preparation of complex macromolecules and their post-modification under visible light. According to the nature of photocatalysts, different polymerizations can be achieved using a range of wavelengths (from blue to near Infrared). We demonstrated that a large range of photocatalysts can activate a photoinduced electron/energy transfer (PET) process, which initiates a reversible addition fragmentation chain transfer polymerization (RAFT). More recently, we exploited photocatalyst property to perform specific monoradical addition, which can be exploited for the synthesis of sequence defined polymers. In the second part, we will give an overview of polymeric nanoparticles for therapeutic applications. These systems can offer significant improvements in the temporal and spatial control of drug delivery. In this talk, different polymeric nanoparticles that have been specifically designed to deliver anti-cancer drugs and to image specific tissue, will be discussed. The first system presented will be based on pH- and redox- responsive nanoparticles which are able to deliver different payloads in different cellular compartments. As an example, the delivery of nitric oxide will be presented using these nanoparticles for the treatment of liver fibrosis and neuroblastoma. We have also demonstrated synergistic effect when we combine nitric oxide (NO) with chemotherapy drugs for the treatment in multi-drugs resistance in cancer. In a second part of this talk, the synthesis of new hybrid organic/inorganic nanomaterials, based on iron oxide, gold and gadolinium, will be reported for use as MRI contrast agents. The effect of the architecture and the nature of polymers will be correlated with the magnetic properties of these nano-objects. In addition, the polymeric shell of these nanomaterials can be designed to conjugate with anti-cancer drugs.
Biography: Prof Cyrille Boyer received his Ph.D. from the University of Montpellier II. After working with Dupont Performance Elastomers, Cyrille moved to UNSW in the centre for advanced macromolecular design. He was awarded the SCOPUS Young Researcher of the year Award in 2012, one of the six 2015 Prime Minister's Science Prizes (Malcolm McIntosh Prize for Physical Scientist of the year), the 2016 LeFevre Memorial Prize and nominated as one of the inaugural Knowledge Nation 100 selected by the Knowledge Society, guided by Australia's Chief Scientist, Professor Ian Chubb and senior commentators from The Australian newspaper. Cyrille’s research has also been recognized by several international awards, including ACS Biomacromolecules/Macromolecules Award and Journal of Polymer Science Innovation Award. Cyrille is the co-director of Australian Centre for Nanomedicine. This centre regroups 12 academics, 25 post-docs and research associates and 80 PhD students. Cyrille's research interests mainly cover the use of photoredox catalysts to perform living radical polymerization and polymer post-modification, hybrid organic–inorganic nanoparticles for imaging and drug delivery. Cyrille has published over 175 research articles and eight patents which have gathered over 9000 citations resulting in H-index of 55.
（报告联系人：朱健老师）