报告题目：AApeptides: From Structure to Function

报告人：蔡健峰（ University of South Florida ）

报告时间：2017年5月17日（星期三）下午 15:00

报告地点：材料与化学化工学部907幢1445室

报告摘要：

The identification and development of sequence-specific peptidomimetics is of significance in bioorganic chemistry and chemical biology. A new class of peptidomimetics termed "AApeptides“ was recently developed by our group. The synthesis of AApeptides can be conveniently achieved on the solid phase. Similar to other peptidomimetics, AApeptides are resistant to proteolytic degradation, and possess limitless potential to introduce chemically diverse functional groups. Moreover, they are able to fold into well-defined secondary and tertiary structures. The functions of AApeptides have also been recently explored, including rational design of AApeptides for the mimicry of the primary and secondary structure of bioactive peptides, and combinatorial library for the discovery of potential molecular probes and drug leads.

个人简介：

Postdoctoral Associate, Bioorganic Chemistry, Yale University, 2007-2009 PhD, Advisor: Professor Andrew D. Hamilton. Bioorganic Chemistry, Washington University in St. Louis

2006 MS, Advisor: Professor John-Stephen Taylor. Nanjing University, China, 2000.  BS, Nanjing University, China, 1997;

POSITIONS AND EMPLOYMENT

2007-2009 Postdoctoral Associate, Yale University, New Haven, CT.

2009-2015 Assistant Professor, University of South Florida, Tampa, FL.

2009-present Member, Drug Discovery Program, Moffitt Cancer Center, Tampa, FL. 2015-present Associate Professor, University of South Florida, Tampa, FL;

AWARDS AND RECOGNITIONS:

2016 Outstanding reviewer, Journal of Medicinal Chemistry.

2015 Outstanding reviewer, Journal of Medicinal Chemistry.

2015 USF Faculty Outstanding Research Achievement Award.

2015 Biomatik Distinguished Junior Faculty Award, the Chinese-American Chemistry & Chemical Biology Professors Association (CAPA).

2014 Excellence in reviewing, European Journal of Medicinal Chemistry.

2014 NSF Career Award.

2014 ChemComm Emerging Investigator.

2012 New Investigator award, Florida Bankhead Coley Cancer Research Program. 2011 Ralph E. Powe Junior Faculty Enhancement Award, Oak Ridge Associated Universities (ORAU)
RESEARCH INTEREST : Bioorganic, Chemical Biology, Medicinal Chemistry, Biomaterials, and Biophysics
Research Focus: Design, synthesis and investigation of bioactive peptidomimetics; development of novel nanomaterials.

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                                                                      （报告联系人：张正彪老师）