报告题目：Progress in the synthesis and purification of cyclic polymers

报告人：Scott M. Grayson（Tulane University, New Orleans, LA, USA）

报告时间：2017年5月22日（星期一）上午 9:30

报告地点：材料与化学化工学部907幢1445室

报告摘要：

The synthesis of ring polymers and their physical characterization have been the subject of substantial efforts since the first reports of high molecular weight cyclic polymers nearly 40 years ago.   Despite these numerous investigations, a number of fundamental questions about the role of macromolecular topologies remain unresolved, in large part because of the difficulty in preparing cyclic polymers in high purity.  Studies have confirmed that less than 1% of linear impurities can have a profound effect on some physical properties.  A number of recent synthetic improvements offer promise to address this limitation.  One such method, the “click” cyclization approach, exhibits unprecedented versatility in backbone chemistry and provides ring polymers and their exact linear analogs for direct physical comparison.  Recent efforts have confirmed the ability to prepare cyclic polymers with greater than 99.5% purity.  Furthermore, techniques have been advanced that promise to remove non-cyclic impurities from cyclic samples so as to further improve the purity of cyclic samples.  By generating cyclic polymers with exceptional purity, the physical properties of these exotic molecules can be better understood.

个人简介：

Scott M. Grayson complete his PhD in Chemistry from the University of California, Berkeley (2002), studying the role of polymer architecture for dendritic drug carriers under Jean M. J. Fréchet.  Following post-doctoral studies in the laboratories of C. Grant Willson at the University of Texas, he was appointed as a professor at the Department of Chemistry at Tulane University in New Orleans, Louisiana, USA.  He now holds the Joseph H. Boyer Professorship of Chemistry at Tulane where he explores the synthesis and applications of well-defined, yet complex macromolecular structures.  His research group has recently focused on the synthesis of amphiphilic and cyclic polymers for applications including transdermal drug delivery and gene therapies.

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