报告题目：Molecular Engineering for the Design of Nanostructured Materials

报告人：Prof. Sébastien Perrier

The University of Warwick &Monash University

时间：2017年6月23日（星期五）上午9:30-11:00

地点：独墅湖校区907楼-1445室

CV:Professor Sébastien Perrier graduated from the Ecole National Supèrieure de Chimie de Montpellier, France, in 1998. He undertook his PhD at the University of Warwick (England) in polymer chemistry, and spent one year as a postdoctoral fellow at the Centre for Advances Macromolecular Design (University of New South Wales, Australia). He started his academic career at Leeds in 2002 as a lecturer, then moved to the University of Sydney in 2007 as director of the Key Centre for Polymers & Colloids. In October 2013, he was appointed as the Monash-Warwick Alliance Chair in Polymer Chemistry, a joint appointment between the Chemistry Department and the Medical School at the University of Warwick (UK) and the Faculty of Pharmacy at Monash University (Australia). His team focuses on the use of macromolecular engineering to design functional nanostructured materials, with applications ranging from material science to nanotechnology and nanomedicine. He has published nine book chapters and ca. 150 articles, which have received over 10,000 citations (h-index 50), and supervised to date 25 PhD students. He has made strong contributions to his discipline, as Chair of the RACI Polymer Division (2011), member of the IUPAC Polymer group and he was appointed from 2011 to 2013 as panel member of the Australian Research Council College of Experts. He is also a member of the editorial boards of Soft Matter, Macromolecules, Polymers, Polymer Chemistry, European Polymer Journal,Click Chemistry, ACS Macro Letters, Chemical Communicationsand Chemical Society Reviews. His recent awards include the Macro Group UK Young Researcher Award (2006), the Rennie Memorial Medal (2009), the RACI Applied Research Award (2012), a Future Fellowship (2012), the Australian Academy of Science Le Fèvre Memorial Prize (2013), the Wolfson Merit Award (Royal Society, 2014), the Biomacromolecules / Macromolecules Young Investigator Award (ACS, 2014) and the IUPAC / Samsung Young Polymer Scientist Award (IUPAC, 2014).

Abstract:Chemists are remarkably proficient at directing the synthesis of small molecules, but fine-tuning the structures of large molecules, such as those found in polymers, is far more taxing. Despite many years of research, the field of macromolecular engineering i.e. the preparation of large molecules with strict control over their size and chemical groups has many mountainous challenges yet to overcome. Nature provides endless examples of precisely engineered macromolecules; proteins, for instance, which contain amino-acid side-chains that are accurately positioned, often in a way that determines the proteins’ roles. Synthetic chemists have tried to recreate nature’s exceptional control over macromolecules, and in so doing they have designed new materials with precisely defined structures, for use in applications ranging from materials to medicine.

The lecture will describe new synthetic paths to design macromolecules showing excellent control over their topology and functionality. These synthetic macromolecules are then exploited to directly form functional materials, or associated to biopolymers such as peptides to form natural / synthetic polymer conjugates. The exploitation of these well-defined macromolecules for the design of functional nanostructured materials via molecular self-assembly and self-organization will be discussed, with examples of applications in the material and biomedical fields.

Figure 1. Examples of multiblock segmented copolymers (left) and peptide / polymer conjugates nanotubes (right).

Selected Publications:

1 Moraes, J.; Ohno, K.; Maschmeyer, T.; Perrier, S. Small2015, 11, 482-488.

2 Danial, M.; My-Nhi Tran, C.; Jolliffe, K. A. Perrier, S. J. Am. Chem. Soc. 2014, 136, 8018-8026.

3 Danial, M.; My-Nhi Tran, C.; Young, P. G.; Perrier, S.; Jolliffe, K. A. Nat. Commun.2013, DOI: 10.1038/ncomms3780.

4 Gody, G.; Maschmeyer, T.; Zetterlund, P.B.; Perrier, S. Nat. Commun.2013, DOI: 10.1038/ncomms3505.

5 Chapman, R.; Warr, G. G; Jolliffe, K. A.; Perrier, S. Adv. Mater.2013, 25, 1170-1172.

6 Zhao, W.; Gody, G.; Dong, S.; Zetterlund, P. B.; Perrier, S. Polym. Chem. 2014, 5, 6990-7003.

7 Gody, G.; Rossner, C.; Moraes, J.; Vana, P.; Maschmeyer, T.; Perrier, S. J. Am. Chem. Soc.2012, 134, 12596-12603.

8 Konkolewicz, D.; Gray-Weale, A.; Perrier, S. J. Am. Chem. Soc.2009, 131, 18075-18077.

9 Kakwere, H.; Perrier, S. J. Am. Chem. Soc.2009, 131, 1889-1895.

10 Perrier, S.; Takolpuckdee, P.; Mars, C. A. Macromolecules 2005, 38, 2033-2036.

Recent Reviews:

1 Zetterlund, P.; Thickett, S.; Perrier, S.; Bourgeat-Lami, E.; Lansalot, M. Chem. Rev., 2015, 115, 9745-9800.

2 Cobo, I.; Li, M.; Sumerlin, B. S.; Perrier, S. Nat. Mater.2015, 14, 143-159.

3 Semsarilar, M.; Perrier, S. Nat. Chem. 2010, 2, 811-820.

4 Boyer, C.; Bulmus, V.; Davis, T.P.; Ladmiral, V.; Liu, J.; Perrier, S. Chem. Rev.2009, 109, 5402-5436.

5 Perrier, S.; Takolpuckdee, P. J. Polym. Sci., Part A: Polym. Chem. 2005,43, 5347-5393.

欢迎感兴趣的老师和同学参加。